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KMID : 0371320000580050614
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Journal of the Korean Surgical Society
2000 Volume.58 No. 5 p.614 ~ p.621
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Outcome of Surgical Excision for Isolated Locoregional Recurrence of Breast Cancer
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손병호/Byung Ho Son
이병찬/윤호성/곽희숙/장혜숙/안세현/Pyung Chan Lee/Ho Sung Yoon/Hi Suk Kwak/Hyesook Chang/Sei Hyun Ahn
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Abstract
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Purpose
Locoregional recurrence of breast cancer after surgery has been regarded as a harbinger of distant metastases. The present study was undertaken to determine survival following surgical excision of isolated locoregional recurrence and to analyze
prognostic factors for their impact on survival after locoregional recurrence. Also, this study may provide information on the group that benefits from surgical management. Methods
From March 1993 to December 1998, of 43 patients with isolated locoregional recurrence after breast cancer surgery, 26 patients were treated with surgical excision with or without irradiation. Survival was retrospectively analyzed according to
prognostic factors. Results
The median follow-up was 15 months. The 3-year disease-free survival rates were 50% for locoregional recurrences treated with surgical resection and 6% for patients treated without surgery (p=0.04), and the overall survival rates were 63% and
14%,
respectively (p=0.07). Univariative analysis demonstrated that the initial axillary node status and the disease-free interval were significant prognostic factors for overall survival (p=0.04 and p=0.06, respectively). The disease-free interval
from
surgery to recurrence was also a significant prognostic factor for disease-free survival (p=0.03). Conclusion
These results suggest that patients suffering from isolated locoregional recurrence of breast cancer after a long disease-free interval and an initial node negative status may survive for long periods of time with aggressive surgical treatment.
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KEYWORD
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